纵向课题: 具有肿瘤靶向性的岩藻聚糖硫酸酯及其活性低聚糖结构特征研究山东省自然科学基金面上项目 10万元 2024.01-2026.12 主持 基于岩藻多糖的清除幽门螺旋杆菌功能性食品的研究与开发山东省科技型中小企业创新能力提升工程项目50万元 2023.07-2025.07 主持 具有肿瘤靶向性的岩藻聚糖硫酸酯纳米粒药物载体研究山东省自然科学青年基金10万元 2019.07-2022.07 主持 基于岩藻聚糖硫酸酯的pH敏感性口服纳米运载体系研究 科教产融合创新试点工程项目10万元 2022.01-2023.12 主持 海洋生物活性成分的稳态化与高效递送技术研究山东省科学院青年基金 10万元 2019.01-2020.12 主持 海洋功能食品组方设计与稳态化技术研究 国家重点研发计划课题 438万元 2018.07-2021.12 参与 海参产业高效智能关键技术创新与示范 山东省重点研发计划(重大科技创新工程) 91万元 2021.12-2024.12 参与 海洋天然高分子多糖促伤口愈合敷料的研发 山东省科学院院地产学研协同创新基金项目 2023.01-2024.12 45万元 参与
主要论文: Xinyue Gai, Hui Zhang, ......,Xue Liu*, Airong Jia*. Sulfated polysaccharide from Apostichopus japonicus and its inhibition effects on Helicobacter pylori in vitro and in vivo. International Journal of Biological Macromolecules, 2025, 330(Pt 1),148027.(二区,Top) Xinyue Gai#, Yinghao Bi#, ......, Xue Liu*, Airong Jia*. Multifunctional Carboxymethyl Chitosan/Sodium Alginate/Fucoidan Hydrogel as a Dressing for Hemostasis and Skin Wound Healing. Gels, 2025, 11(12), 950.(二区) Xue Liu, Xin Liu, Mikhail I. Kusaykin, et al.Structural characterization of a P-selectin and EGFR dual-targeting fucoidan from Sargassum fusiforme. International Journal of Biological Macromolecules, 2022, 199, 86-95. (一区, Top) Xue Liu, Xiangyu Xi, Airong Jia, et al. A fucoidan from Sargassum fusiforme with novel structure and its regulatory effects on intestinal microbiota in high-fat diet-fed mice.Food Chemistry,2021,358,129908.(一区, Top) Xue Liu, Peng Du, Xiao Liu, et al. Anticoagulant Properties of a Green Algal Rhamnan-type Sulfated Polysaccharide and Its Low-molecular-weight Fragments Prepared by Mild Acid Degradation. Marine Drugs. 2018, 16(11), 445. (二区) Xue Liu, Shuyao Wang, Sujian Cao, et al. Structural Characteristics and Anticoagulant Property In Vitro and In Vivo of a Seaweed Sulfated Rhamnan.Marine Drugs.2018, 16(7), 243. (二区) Xue Liu, Jiejie Hao, Xiaoxi He, et al. A rhamnan-type sulfated polysaccharide with novel structure from Monostroma angicava Kjellm(Chlorophyta) and its bioactivity.Carbohydrate Polymers, 2017, 173, 732–748. (二区,Top) Xue Liu, Wen Zhao, Xinyue Gai, et al. Anticoagulant and angiotensin-converting enzyme inhibitory activities of a fucoidan fromSargassum horneriand its low molecular weight fragments prepared by acid degradation. Natural product research, 2025, Mar 31, 1-10. (三区) Xue Liu, Wen Zhao, Xinyue Gai, et al. Structural characterization of a novel fucoidan from Sargassum horneri for anticancer drug delivery. Carbohydr Research. 2025, 553,109501. (三区) 毕英豪, 都红芳, ..., 刘雪*.仿刺参肠高抗凝血活性多糖筛选及其结构解析. 食品科学, 2025, 46(6): 47-53. (EI) 刘雪, 鞠文明, 徐静沂,等. 基于铜藻岩藻聚糖硫酸酯的负载岩藻黄质纳米粒子制备与分析. 食品科学, 2023, 44(12): 95-101.(EI) 刘雪, 任晨瑜, 刘新, 等. 羊栖菜褐藻糖胶寡糖组分分析及抗凝血活性. 食品科学, 2022, 43(12): 260-266. (EI) 刘雪,姜竹茂,毕浩然,等. 新型壳聚糖-岩藻聚糖硫酸酯纳米粒子研究. 中国食品学报,2021, 21(5):41-47.(EI)
专著: Airong Jia, Miansong Zhang,Xue Liu, et al. (2023). Ready-to-Eat Sea Cucumber Products and Collagen Stabilization Technology. Part of the Advances in Marine Bioprocesses and Bioproducts book series (AMBB). Springer, Cham,193-227. 发明专利: 刘雪,贾爱荣,刘昌衡,史亚萍,崔婷婷,白新峰,孙继敏,徐振鲁. 一种抗凝血褐藻糖胶寡糖及其制备方法,ZL202011439776.5 刘雪,贾爱荣,刘昌衡,张绵松,史亚萍,崔婷婷,白新峰,孙继敏,徐振鲁. 一种肿瘤靶向性岩藻聚糖硫酸酯及其制备方法,ZL202011436361.2 刘雪,刘昌衡,贾爱荣,张绵松,史亚萍,王加祥,刘新,白新峰。一种海带表面光滑皮的快速脱除方法,ZL201910588088.6 刘雪,贾爱荣,张绵松,刘昌衡,史亚萍,崔婷婷,孙继敏,徐振鲁。改性褐藻胶及制备方法与其在制备促进胃肠蠕动药物中的应用,ZL202110913168.1 刘雪,贾爱荣,张绵松,刘昌衡,崔婷婷,徐振鲁。一种高抗凝血海参肠多糖及其制备方法与应用,ZL202211412950.6 刘雪,盖鑫悦,贾爱荣,张绵松,崔婷婷。一种具有预防和治疗幽门螺杆菌感染的海参多糖及其制备方法与应用,2025104262317 刘雪,毕英豪,贾爱荣,张绵松,崔婷婷。一种海洋高分子多糖水凝胶伤口敷料及其制备方法与在制备医疗器械中的应用,2024116182249 刘雪,赵文,贾爱荣,张绵松,崔婷婷。一种岩藻多糖及其制备方法和应用,2024113526748 刘雪,贾爱荣,盖鑫悦,毕英豪,张绵松,崔婷婷,徐振鲁。一种抗幽门螺杆菌海参肠岩藻多糖及其制备方法与应用,2024103876092 刘雪,都红芳,毕英豪,贾爱荣,张绵松,崔婷婷,徐振鲁,王凌英。一种ACE抑制低分子量岩藻多糖及其制备方法、应用,202311465625.0 刘雪,刘昌衡,贾爱荣,刘新,史亚萍,王加祥,张绵松,白新峰。新型负载岩藻黄质的岩藻聚糖硫酸酯纳米粒子的制备方法,201910613575.3
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